Vismodegib: A smoothened inhibitor for the treatment of advanced basal cell carcinoma
نویسندگان
چکیده
منابع مشابه
Vismodegib (erivedge) for advanced Basal cell carcinoma.
Vismodegib (Erivedge) for advanced basal cell carcinoma.
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Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. If left untreated, BCCs can become locally aggressive or even metastasize. Currently available treatments include local destruction, surgery, and radiation. Systemic options for advanced disease are limited. The Hedgehog (Hh) pathway is aberrantly activated in a majority of BCCs and in other cancers. Hh pathway inhibitors ar...
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Basal-cell carcinoma is a commonly occurring skin malignancy that has the potential to progress into locally invasive or resistant disease, as well as spread distantly. Due to advances in the molecular understanding of the disease over the last two decades, it has been discovered that the Hedgehog pathway plays an important role in the pathogenesis of this disease and can be exploited as a trea...
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Smoothened inhibitors have recently emerged as a nonsurgical, targeted therapy for treating advanced basal cell carcinomas (BCC) [8]. This novel small-molecule drug class suppresses Hedgehog pathway signaling by binding the membrane protein, Smoothened [7, 9]. Dysregulation of Hedgehog signaling is a hallmark of BCCs and is thought to play an integral role in maintaining cancer growth [1]. Trea...
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IMPORTANCE Vismodegib is a targeted agent recently approved for treating patients who develop recurrent or locally advanced basal cell carcinoma (BCC), and will inevitably be integrated into existing therapy for advanced BCC as it becomes increasingly used. Improved understanding of how vismodegib interacts with other treatment modalities, including radiotherapy, would help optimize multidiscip...
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ژورنال
عنوان ژورنال: Indian Dermatology Online Journal
سال: 2013
ISSN: 2229-5178
DOI: 10.4103/2229-5178.120685